SPNS3

Across TCGA cell cohorts, SPNS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,974 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPNS3-associated GO terms across cancer lineages are Regulation of CD8-positive, alpha-beta T cell activation, Regulation of lymphocyte migration, and Positive regulation of sodium ion transmembrane transport. Each is linked with SPNS3 in more than 7 cancer types. Because this analysis shows association rather than direction, both SPNS3-to-partner and partner-to-SPNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of CD8-positive, alpha-beta T cell activation grouped by SPNS3-low versus SPNS3-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS3→partner) and Y-score (partner→SPNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of CD8-positive, alpha-beta T cell activation →	+0.086	+0.373	.003	.006	3	8
PANCREAS	Regulation of lymphocyte migration →	+0.067	+0.862	.003	<.001	3	7
BREAST	Positive regulation of sodium ion transmembrane transport →	+0.179	+0.694	<.001	.001	3	7
LUNG_NSCLC_LUAD	Regulation of potassium ion import →	+0.195	+0.867	<.001	<.001	3	7
LARGE_INTESTINE	Tetrapyrrole metabolic process →	-0.056	-0.638	<.001	.005	3	7
BLOOD_Leukemia	Macropinocytosis →	+0.120	+1.489	.003	.009	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,974 associations by consensus.

Regulation of CD8-positive, alpha-beta T cell activation by SPNS3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →