SPNS3

Across TCGA cell cohorts, SPNS3 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPNS3-associated genes across cancer lineages are PRR30, C16orf92, and SLC32A1. Each is linked with SPNS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS3-to-partner and partner-to-SPNS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by SPNS3-low versus SPNS3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS3→partner) and Y-score (partner→SPNS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRR30 →	+0.017	+3.684	<.001	.004	3	2
SKIN	C16orf92 →	+0.041	+4.415	<.001	.007	3	2
BLOOD_Leukemia	SLC32A1 →	+0.752	+4.223	<.001	.001	3	1
BLOOD_Leukemia	GML →	+0.092	+4.889	<.001	<.001	3	1
BLOOD_Leukemia	LGI1 →	+0.066	+4.539	<.001	<.001	3	1
BLOOD_Leukemia	CPN1 →	+0.161	+3.820	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

PRR30 by SPNS3 expression — BLOOD_Leukemia

Explore this box plot interactively →