SPNS2

Across TCGA patient cohorts, SPNS2 mutation is significantly associated with the RNA expression of many other genes, with 940 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPNS2-associated genes across cancer lineages are SMIM28, RN7SL248P, and RNU6-709P. Each is linked with SPNS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPNS2-to-partner and partner-to-SPNS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM28 grouped by SPNS2-low versus SPNS2-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS2→partner) and Y-score (partner→SPNS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	SMIM28 →	+0.119	+4.069	.002	.005	3	3
CESC	RN7SL248P →	+0.127	+6.000	<.001	<.001	3	2
COAD	RNU6-709P →	+0.492	+5.142	<.001	.002	3	2
LUSC	RNU4-61P →	+0.613	+5.978	<.001	.002	3	2
BRCA	MIR6515 →	+0.717	+8.055	<.001	.007	3	1
CESC	IGBP1P5 →	+0.023	+4.559	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 940 associations by consensus.

SMIM28 by SPNS2 expression — CESC

Explore this box plot interactively →