SPNS1

Across TCGA cell cohorts, SPNS1 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPNS1-associated genes across cancer lineages are PRAMEF10, PRAMEF33, and KRTAP9-1. Each is linked with SPNS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPNS1-to-partner and partner-to-SPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by SPNS1-low versus SPNS1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS1→partner) and Y-score (partner→SPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRAMEF10 →	+0.386	+5.754	<.001	.002	3	1
CNS	PRAMEF33 →	+0.576	+5.321	<.001	.005	3	1
SKIN	KRTAP9-1 →	+0.023	+4.022	<.001	.006	3	1
BLOOD_Leukemia	EPPIN →	+0.005	+2.922	<.001	.009	3	1
BLOOD_Leukemia	SLCO1B3 →	+0.173	+3.680	.001	.003	3	1
BLOOD_Leukemia	SLC17A2 →	+0.011	+3.362	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PRAMEF10 by SPNS1 expression — CNS

Explore this box plot interactively →