SPNS1

Across TCGA cell cohorts, SPNS1 mutation is significantly associated with the mutation status of many other genes, with 3,171 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPNS1-associated genes across cancer lineages are CACNA2D1, EMSY, and TIAM1. Each is linked with SPNS1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPNS1-to-partner and partner-to-SPNS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNA2D1 grouped by SPNS1-low versus SPNS1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPNS1→partner) and Y-score (partner→SPNS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CACNA2D1 →	+2.498	+2.624	.008	.008	1	4
BLOOD_Leukemia	EMSY →	+4.498	+3.700	<.001	<.001	1	4
SKIN	TIAM1 →	+2.450	+3.402	.005	.005	1	4
SKIN	GAB3 →	+4.357	+4.053	.001	.001	1	4
STOMACH	SLC29A2 →	+4.807	+4.807	.008	.008	1	3
STOMACH	TUBB3 →	+4.807	+4.807	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,171 associations by consensus.

CACNA2D1 by SPNS1 expression — BLOOD_Leukemia

Explore this box plot interactively →