Across TCGA patient cohorts, SPN mutation is significantly associated with the RNA expression of many other genes, with 3,397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPN-associated genes across cancer lineages are GPATCH3, ANXA2P2, and COPS8P1. Each is linked with SPN in more than 2 cancer types. Because this analysis shows association rather than direction, both SPN-to-partner and partner-to-SPN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPN→partner) and Y-score (partner→SPN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPATCH3 →	+0.332	+2.820	.004	.001	3	3
UCEC	ANXA2P2 →	+0.885	+3.917	<.001	<.001	3	3
LUAD	COPS8P1 →	+0.098	+4.481	.001	.009	3	3
UCEC	CCNB2 →	+0.698	+3.732	<.001	<.001	3	3
UCEC	CHAF1B →	+0.699	+3.906	<.001	<.001	3	3
UCEC	H2AZ1 →	+0.634	+2.491	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,397 associations by consensus.

Exploration

SPN survival (RNA) · tumor vs normal (RNA) · all SPN data types