SPIRE2

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, SPIRE2 mutation is significantly associated with the RNA expression of many other genes, with 1,790 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIRE2-associated genes across cancer lineages are LINC02340, TUBGCP5, and CASC23. Each is linked with SPIRE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIRE2-to-partner and partner-to-SPIRE2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIRE2→partner) and Y-score (partner→SPIRE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECLINC02340 →+0.282+2.326.004.00432
UCECTUBGCP5 →+0.422+2.550.001<.00132
BLCACASC23 →+0.018+4.175.002<.00132
BLCALHX5-AS1 →+0.663+2.589<.001.00932
COADDNAAF4-CCPG1 →+0.010+3.521<.001.00132
UCECSLC25A4 →+0.508+3.595.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,790 associations by consensus.

Exploration