SPINT4

Across TCGA patient cohorts, SPINT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,583 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPINT4-associated GO terms across cancer lineages are Vesicle-mediated transport in synapse, Regulatory ncRNA processing, and Peptidyl-lysine modification. Each is linked with SPINT4 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPINT4-to-partner and partner-to-SPINT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vesicle-mediated transport in synapse grouped by SPINT4-low versus SPINT4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT4→partner) and Y-score (partner→SPINT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Vesicle-mediated transport in synapse →	+0.040	+0.378	<.001	<.001	3	14
STAD	Regulatory ncRNA processing →	+0.047	+0.232	<.001	<.001	3	14
STAD	Peptidyl-lysine modification →	+0.057	+0.284	<.001	<.001	3	14
STAD	Cytosolic transport →	+0.060	+0.262	<.001	<.001	3	14
ESCA	Regulation of protein binding →	+0.065	+0.462	<.001	<.001	3	14
STAD	Lysosomal transport →	+0.059	+0.253	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,583 associations by consensus.

Vesicle-mediated transport in synapse by SPINT4 expression — ESCA

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