SPINT4

Across TCGA patient cohorts, SPINT4 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible SPINT4-associated genes across cancer lineages are RNU6-73P, MTND2P22, and MARK2P5. Each is linked with SPINT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT4-to-partner and partner-to-SPINT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-73P grouped by SPINT4-low versus SPINT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT4→partner) and Y-score (partner→SPINT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-73P →	+0.714	+6.226	<.001	.001	3	1
UCEC	MTND2P22 →	+0.101	+5.420	.005	.005	3	1
UCEC	MARK2P5 →	+0.095	+5.694	<.001	.003	3	1
UCEC	LINC01216 →	+0.177	+5.852	<.001	.003	3	1
UCEC	MIR3692 →	+0.639	+6.877	<.001	<.001	3	1
LUAD	OR5I1 →	+0.034	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

RNU6-73P by SPINT4 expression — UCEC

Explore this box plot interactively →