SPINT4

Across TCGA cell cohorts, SPINT4 RNA expression is significantly associated with the mutation status of many other genes, with 39 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPINT4-associated genes across cancer lineages are MAP1A, UGGT2, and ZFR2. Each is linked with SPINT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINT4-to-partner and partner-to-SPINT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP1A grouped by SPINT4-low versus SPINT4-high in LUNG_NSCLC_LUSC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINT4→partner) and Y-score (partner→SPINT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAP1A →	+4.643	+0.063	.008	<.001	3	1
LUNG_NSCLC_LUAD	UGGT2 →	+5.228	+0.051	.005	<.001	3	1
LUNG_NSCLC_LUAD	ZFR2 →	+5.228	+0.051	.005	<.001	3	1
LUNG_NSCLC_LUAD	COMP →	+5.228	+0.047	.005	<.001	3	1
LUNG_NSCLC_LUAD	SMOC2 →	+3.491	+0.030	.002	<.001	3	1
LUNG_NSCLC_LUAD	KYNU →	+5.228	+0.058	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

MAP1A by SPINT4 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →