SPINT1-AS1

Across TCGA pan-cancer cohorts, SPINT1-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SPINT1-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SPINT1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SPINT1-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRC, UVM, and KIRP are the cancer types where SPINT1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.728	0.539	<.001	101	view →
UVM	DFS	Median	All	0.751	0.410	<.001	97	view →
KIRP	DFS	Median	II,III,IV	1.000	0.453	<.001	72	view →
SKCM	OS	Tertile	II,III,IV	0.669	0.826	<.001	52	view →
ACC	DFS	Tertile	All	0.245	0.566	.002	50	view →
MESO	DFS	Quartile	II,III,IV	0.563	0.295	.007	37	view →
THCA	DFS	Tertile	All	0.940	0.748	<.001	37	view →
BLCA	DFS	Tertile	All	0.575	0.469	.019	34	view →
HNSC	OS	Median	III,IV	0.806	0.686	.002	26	view →
LGG	DFS	Median	All	0.679	0.787	.003	24	view →
UCS	OS	Tertile	III,IV	0.354	0.671	.004	18	view →
COAD	OS	Quartile	III,IV	0.628	0.876	.007	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SPINT1-AS1–KIRC (OS)

Open the KIRC breakdown →