SPINT1-AS1

Across TCGA pan-cancer cohorts, SPINT1-AS1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SPINT1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where SPINT1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPINT1-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and BLCA are the cancer types where SPINT1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPINT1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−2.264	<.001	11	view →
KIRC	Male	IV	−1.531	<.001	11	view →
BLCA	All	All	+1.517	.007	7	view →
BRCA	All	All	+0.614	<.001	6	view →
CHOL	Male	All	+3.806	<.001	5	view →
UCEC	All	All	+1.990	<.001	4	view →
STAD	All	All	+1.003	.012	3	view →
COAD	Female	III,IV	−0.916	.017	2	view →
LIHC	Female	All	+0.844	.012	2	view →
HNSC	Female	All	−0.601	.032	1	view →
THCA	Female	All	+0.286	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SPINT1-AS1–KIRP

Open the KIRP breakdown →