SPINK7

Across TCGA patient cohorts, SPINK7 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPINK7-associated genes across cancer lineages are TSC1, BRCA2, and MEK1. Each is linked with SPINK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK7-to-partner and partner-to-SPINK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSC1 grouped by SPINK7-low versus SPINK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK7→partner) and Y-score (partner→SPINK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TSC1 →	-0.255	-3.169	.006	.020	3	1
UCEC	BRCA2 →	-0.153	-3.162	.028	.019	2	1
UCEC	MEK1 →	+0.554	+3.169	.005	.020	1	1
UCEC	PCNA →	+0.368	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

TSC1 by SPINK7 expression — UCEC

Explore this box plot interactively →