SPINK2

Across TCGA pan-cancer cohorts, SPINK2 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SPINK2 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPINK2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPINK2 expression acts as an unfavorable survival marker.

HNSC and PRAD are the cancer types where SPINK2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.057	0.768	<.001	48	view →
PRAD	OS	Median	All	0.080	0.990	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SPINK2–HNSC (OS)

Open the HNSC breakdown →