SPINK2

Across TCGA pan-cancer cohorts, SPINK2 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SPINK2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SPINK2 RNA is repressed in tumor relative to normal tissue. In most cancer types SPINK2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, THCA, and READ are the cancer types where SPINK2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPINK2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−2.407	<.001	12	view →
THCA	All	III,IV	+1.874	<.001	10	view →
READ	Male	All	−2.140	<.001	7	view →
STAD	All	All	−0.892	.003	7	view →
LUAD	Female	All	+1.134	<.001	4	view →
BRCA	Female	All	−0.201	.009	4	view →
PRAD	All	All	−1.980	<.001	2	view →
LUSC	All	All	+0.571	.010	2	view →
CHOL	Female	All	+0.300	.026	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SPINK2–COAD

Open the COAD breakdown →