SPINK2

Across TCGA patient cohorts, SPINK2 protein abundance is significantly associated with the RNA expression of many other genes, with 950 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPINK2-associated genes across cancer lineages are CSNK2A1, SEC23B, and CHMP4B. Each is linked with SPINK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK2-to-partner and partner-to-SPINK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPINK2 versus CSNK2A1 in LUAD, with a Pearson correlation of -0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK2→partner) and Y-score (partner→SPINK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CSNK2A1 →	-0.501	-1.684	.004	.001	3	1
LUAD	SEC23B →	-0.427	-1.482	.005	.006	3	1
LUAD	CHMP4B →	+0.609	+2.303	.003	.007	3	1
LUAD	MAGT1 →	+0.653	+1.768	.005	.002	3	1
LUAD	LYL1 →	+0.490	+1.519	.004	.005	3	1
LUAD	ICAM2 →	+0.458	+1.580	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

SPINK2 vs CSNK2A1 — LUAD

Explore this scatter interactively →