SPINK2

Across TCGA cell cohorts, SPINK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,399 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPINK2-associated GO terms across cancer lineages are Proton motive force-driven ATP synthesis, Aerobic electron transport chain, and Respiratory electron transport chain. Each is linked with SPINK2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPINK2-to-partner and partner-to-SPINK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proton motive force-driven ATP synthesis grouped by SPINK2-low versus SPINK2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK2→partner) and Y-score (partner→SPINK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Proton motive force-driven ATP synthesis →	+0.110	+0.231	.003	.009	3	9
OVARY	Aerobic electron transport chain →	+0.091	+0.780	<.001	<.001	3	9
OVARY	Respiratory electron transport chain →	+0.086	+0.806	<.001	<.001	3	9
OVARY	ATP synthesis coupled electron transport →	+0.093	+0.749	<.001	<.001	3	9
OVARY	Mitochondrial ATP synthesis coupled electron transport →	+0.093	+0.749	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Negative regulation of RNA catabolic process →	+0.058	+1.002	<.001	.005	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,399 associations by consensus.

Proton motive force-driven ATP synthesis by SPINK2 expression — STOMACH

Explore this box plot interactively →