SPINK2

Across TCGA cell cohorts, SPINK2 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPINK2-associated genes across cancer lineages are OR6T1 and OOSP4B. Each is linked with SPINK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPINK2-to-partner and partner-to-SPINK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6T1 grouped by SPINK2-low versus SPINK2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPINK2→partner) and Y-score (partner→SPINK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6T1 →	+0.048	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.023	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

OR6T1 by SPINK2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →