SPIDR

Across TCGA patient cohorts, SPIDR protein abundance is significantly associated with the RNA expression of many other genes, with 4,571 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPIDR-associated genes across cancer lineages are SERPINE1, TMEM92-AS1, and RAD54B. Each is linked with SPIDR in more than 2 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPIDR versus SERPINE1 in LSCC, with a Pearson correlation of -0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SERPINE1 →	-1.349	-0.542	<.001	.001	3	3
LSCC	TMEM92-AS1 →	-0.709	-0.425	<.001	.001	3	3
LSCC	RAD54B →	+0.574	+0.470	<.001	<.001	3	3
LSCC	CDCA3 →	+0.565	+0.377	.001	.003	3	3
OV	UBE2L6 →	-1.035	-0.839	.001	<.001	3	2
OV	CEP19 →	+0.752	+0.589	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,571 associations by consensus.

SPIDR vs SERPINE1 — LSCC

Explore this scatter interactively →