SPIDR

Across TCGA patient cohorts, SPIDR mutation is significantly associated with the RNA expression of many other genes, with 3,043 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIDR-associated genes across cancer lineages are BUB3, NDUFB6, and LRR1. Each is linked with SPIDR in more than 3 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by SPIDR-low versus SPIDR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.384	+2.490	<.001	.001	3	4
UCEC	NDUFB6 →	+0.468	+3.010	<.001	<.001	3	4
UCEC	LRR1 →	+0.536	+2.928	<.001	<.001	3	4
UCEC	FH →	+0.365	+1.687	.002	.006	3	4
SKCM	CKS2 →	+0.788	+3.195	.002	.009	3	4
SKCM	NDUFA12 →	+0.409	+2.719	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,043 associations by consensus.

BUB3 by SPIDR expression — UCEC

Explore this box plot interactively →