SPIDR

Across TCGA patient cohorts, SPIDR mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIDR-associated genes across cancer lineages are NF2, p38-MAPK, and 14-3-3_beta. Each is linked with SPIDR in more than 2 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NF2 grouped by SPIDR-low versus SPIDR-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	NF2 →	+0.200	+2.999	.032	.035	3	2
BLCA	p38-MAPK →	-0.209	-2.966	.028	.034	3	2
UCEC	14-3-3_beta →	-0.089	-2.432	.010	.018	3	2
UCEC	FASN →	+0.356	+2.070	.009	.001	3	2
UCEC	Ku80 →	+0.190	+1.750	.020	.004	3	2
UCEC	MEK1 →	+0.312	+1.765	.013	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

NF2 by SPIDR expression — BLCA

Explore this box plot interactively →