SPIDR

Across TCGA cell cohorts, SPIDR RNA expression is significantly associated with the go_rna of many other GO terms, with 3,788 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPIDR-associated GO terms across cancer lineages are Regulation of sister chromatid cohesion, Regulation of DNA repair, and Negative regulation of calcium ion export across plasma membrane. Each is linked with SPIDR in more than 12 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of sister chromatid cohesion grouped by SPIDR-low versus SPIDR-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of sister chromatid cohesion →	+0.097	+1.053	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA repair →	+0.062	+1.210	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.069	+1.079	.002	.004	3	12
BLOOD_Lymphoma	Microtubule polymerization →	+0.083	+0.997	<.001	<.001	3	11
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.132	+0.989	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	DNA damage tolerance →	+0.102	+1.274	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,788 associations by consensus.

Regulation of sister chromatid cohesion by SPIDR expression — BLOOD_Lymphoma

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