SPIDR

Across TCGA cell cohorts, SPIDR mutation is significantly associated with the mutation status of many other genes, with 2,086 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPIDR-associated genes across cancer lineages are TEX15, SLX4, and DOT1L. Each is linked with SPIDR in more than 4 cancer types. Because this analysis shows association rather than direction, both SPIDR-to-partner and partner-to-SPIDR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TEX15 grouped by SPIDR-low versus SPIDR-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIDR→partner) and Y-score (partner→SPIDR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TEX15 →	+4.954	+4.392	.008	.008	1	5
PANCREAS	SLX4 →	+5.115	+5.115	.005	.005	1	4
SKIN	DOT1L →	+2.830	+3.548	.009	.009	1	4
LARGE_INTESTINE	FRAS1 →	+1.992	+3.963	.001	.001	1	4
PANCREAS	INHBB →	+5.115	+5.115	.005	.005	1	3
PANCREAS	ARHGAP33 →	+5.115	+5.115	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,086 associations by consensus.

TEX15 by SPIDR expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →