SPIC

Across TCGA patient cohorts, SPIC RNA expression is significantly associated with the go_rna of many other GO terms, with 7,086 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPIC-associated GO terms across cancer lineages are Alpha-beta T cell activation, Antigen receptor-mediated signaling pathway, and Regulation of T cell apoptotic process. Each is linked with SPIC in more than 26 cancer types. Because this analysis shows association rather than direction, both SPIC-to-partner and partner-to-SPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Alpha-beta T cell activation grouped by SPIC-low versus SPIC-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIC→partner) and Y-score (partner→SPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Alpha-beta T cell activation →	+0.129	+0.518	<.001	<.001	2	27
SCLC	Antigen receptor-mediated signaling pathway →	+0.148	+0.668	<.001	<.001	3	26
SCLC	Regulation of T cell apoptotic process →	+0.109	+0.879	<.001	.003	3	25
SCLC	Lymphocyte activation involved in immune response →	+0.075	+0.835	<.001	.005	3	25
SCLC	Interleukin-2 production →	+0.139	+0.577	<.001	<.001	3	25
SCLC	CD4-positive, alpha-beta T cell activation →	+0.119	+0.508	<.001	<.001	2	26

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,086 associations by consensus.

Alpha-beta T cell activation by SPIC expression — SCLC

Explore this box plot interactively →