SPIC

Across TCGA pan-cancer cohorts, SPIC RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SPIC’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SPIC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SPIC is over-expressed in tumor, although a few such as LIHC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and COAD are the cancer types where SPIC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPIC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.443	<.001	9	view →
LIHC	Male	All	−0.521	<.001	6	view →
COAD	All	II,III,IV	−0.118	<.001	6	view →
BRCA	All	All	+0.106	<.001	4	view →
CHOL	All	All	−0.352	.007	2	view →
UCEC	All	IV	+0.339	.013	2	view →
LUSC	Male	All	+0.293	.043	2	view →
THCA	All	All	−0.146	.018	1	view →
KIRP	All	All	+0.097	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SPIC–KIRC

Open the KIRC breakdown →