SPIC

Across TCGA patient cohorts, SPIC mutation is significantly associated with the RNA expression of many other genes, with 1,542 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIC-associated genes across cancer lineages are NPAP1P7, LINC01194, and LSM11. Each is linked with SPIC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIC-to-partner and partner-to-SPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPAP1P7 grouped by SPIC-low versus SPIC-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIC→partner) and Y-score (partner→SPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPAP1P7 →	+0.713	+3.059	<.001	<.001	3	2
SKCM	LINC01194 →	+0.701	+3.938	.003	<.001	3	2
UCEC	LSM11 →	+0.455	+2.930	<.001	<.001	3	2
UCEC	KIAA1958 →	+0.465	+3.345	.001	.005	3	2
SKCM	R3HCC1L →	+0.812	+3.487	<.001	.002	3	2
UCEC	MORN4 →	+0.417	+3.499	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,542 associations by consensus.

NPAP1P7 by SPIC expression — SKCM

Explore this box plot interactively →