SPIC

Across TCGA patient cohorts, SPIC mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPIC-associated genes across cancer lineages are Fibronectin, STAT3_pY705, and Tuberin. Each is linked with SPIC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIC-to-partner and partner-to-SPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fibronectin grouped by SPIC-low versus SPIC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIC→partner) and Y-score (partner→SPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Fibronectin →	-0.312	-2.575	.030	.010	3	2
UCEC	STAT3_pY705 →	-0.396	-1.990	<.001	.030	3	1
UCEC	Tuberin →	+0.288	+2.999	.014	.035	3	1
UCEC	ATM →	-0.626	-2.115	.001	.019	3	1
UCEC	Caspase-8 →	-0.264	-3.906	.016	<.001	2	2
UCEC	Chk2 →	-0.242	-2.321	.018	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Fibronectin by SPIC expression — UCEC

Explore this box plot interactively →