SPIC

Across TCGA cell cohorts, SPIC RNA expression is significantly associated with the go_rna of many other GO terms, with 347 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible SPIC-associated GO terms across cancer lineages are Regulation of interferon-beta production, Regulation of nucleocytoplasmic transport, and Golgi vesicle budding. Each is linked with SPIC in more than 2 cancer types. Because this analysis shows association rather than direction, both SPIC-to-partner and partner-to-SPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of interferon-beta production grouped by SPIC-low versus SPIC-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIC→partner) and Y-score (partner→SPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Regulation of interferon-beta production →	+0.042	+0.392	.001	.009	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of nucleocytoplasmic transport →	+0.060	+0.032	.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle budding →	+0.113	+0.046	.002	.009	3	2
UPPER_AERODIGESTIVE_TRACT	Regulation of nuclear-transcribed mRNA poly(A) tail shortening →	+0.087	+0.038	<.001	.001	3	2
UPPER_AERODIGESTIVE_TRACT	Glomerular epithelium development →	+0.185	+0.058	<.001	.007	3	2
UPPER_AERODIGESTIVE_TRACT	Epidermis development →	+0.088	+0.064	.002	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 347 associations by consensus.

Regulation of interferon-beta production by SPIC expression — BLOOD_Lymphoma

Explore this box plot interactively →