SPIC

Across TCGA cell cohorts, SPIC mutation is significantly associated with the RNA expression of many other genes, with 1 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SPIC-associated genes across cancer lineages are DCX. Each is linked with SPIC in more than 1 cancer types. Because this analysis shows association rather than direction, both SPIC-to-partner and partner-to-SPIC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCX grouped by SPIC-low versus SPIC-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPIC→partner) and Y-score (partner→SPIC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DCX →	+0.140	+4.139	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 1 strongest of 1 associations by consensus.

DCX by SPIC expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →