SPI1

Across TCGA patient cohorts, SPI1 mutation is significantly associated with the RNA expression of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPI1-associated genes across cancer lineages are RPL31P3, OR4K12P, and H4C7. Each is linked with SPI1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPI1-to-partner and partner-to-SPI1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL31P3 grouped by SPI1-low versus SPI1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPI1→partner) and Y-score (partner→SPI1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RPL31P3 →	+0.180	+5.157	<.001	.007	3	2
SKCM	OR4K12P →	+0.034	+4.212	<.001	.007	3	2
LIHC	H4C7 →	+0.124	+5.008	<.001	.004	3	1
UCEC	AKR1B10P2 →	+0.043	+3.136	.003	.008	3	1
UCEC	MIR4744 →	+0.539	+2.863	<.001	.003	3	1
UCEC	RN7SL376P →	+0.281	+2.663	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

RPL31P3 by SPI1 expression — LUAD

Explore this box plot interactively →