SPHK2

Across TCGA patient cohorts, SPHK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,350 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SPHK2-associated proteins across cancer lineages are MYEF2, PPP5C, and BCL11A_S608. Each is linked with SPHK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPHK2 versus MYEF2 in LSCC, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MYEF2 →	+0.722	+0.374	<.001	<.001	3	5
PDAC	PPP5C →	+0.291	+0.580	<.001	<.001	3	5
LSCC	BCL11A_S608 →	+1.163	+0.657	.003	.003	3	4
LSCC	BCL11A_S86 →	+0.856	+0.515	.001	<.001	3	4
GBM	TXNDC5 →	-0.598	-0.584	<.001	<.001	3	4
HNSC	RCOR3_T376 →	+0.727	+0.810	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,350 associations by consensus.

SPHK2 vs MYEF2 — LSCC

Explore this scatter interactively →