SPHK2

Across TCGA pan-cancer cohorts, SPHK2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SPHK2 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SPHK2 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SPHK2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, ACC, and UVM are the cancer types where SPHK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.731	0.532	<.001	103	view →
ACC	DFS	Median	All	0.390	0.765	<.001	80	view →
UVM	DFS	Tertile	All	0.432	0.835	.001	68	view →
SKCM	DFS	Median	All	0.657	0.848	<.001	32	view →
LGG	DFS	Median	All	0.675	0.797	<.001	29	view →
MESO	OS	Quartile	III,IV	0.226	0.727	.010	24	view →
UCEC	DFS	Quartile	IV	0.966	0.518	.005	24	view →
LUAD	OS	Median	II,III,IV	0.837	0.664	.010	22	view →
SCLC	DFS	Median	III,IV	0.673	0.389	.021	18	view →
PAAD	OS	Tertile	All	0.545	0.247	.009	17	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	12	view →
COAD	DFS	Median	II,III,IV	0.606	0.715	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SPHK2–HNSC (DFS)

Open the HNSC breakdown →