SPHK2

Across TCGA patient cohorts, SPHK2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,455 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPHK2-associated genes across cancer lineages are HMGXB4, INTS2, and DDX55. Each is linked with SPHK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPHK2 versus HMGXB4 in GBM, with a Pearson correlation of -0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HMGXB4 →	-0.421	-0.211	.001	.002	3	3
LSCC	INTS2 →	-0.366	-0.154	<.001	.001	3	3
LSCC	DDX55 →	-0.524	-0.251	<.001	<.001	3	3
LSCC	SMC2 →	-0.684	-0.228	<.001	<.001	3	3
LSCC	MRPL45 →	-0.502	-0.211	<.001	.001	3	3
LSCC	RPA3 →	-0.503	-0.188	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,455 associations by consensus.

SPHK2 vs HMGXB4 — GBM

Explore this scatter interactively →