SPHK2

Across TCGA patient cohorts, SPHK2 mutation is significantly associated with the RNA expression of many other genes, with 1,319 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPHK2-associated genes across cancer lineages are OR4F5, MIR1269A, and ATP6V1E1P2. Each is linked with SPHK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F5 grouped by SPHK2-low versus SPHK2-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	OR4F5 →	+0.035	+7.429	<.001	<.001	3	2
KIRC	MIR1269A →	+0.354	+5.143	<.001	.008	3	2
UCEC	ATP6V1E1P2 →	+0.102	+1.787	.003	.002	3	2
UCEC	CRYBB2P1 →	+0.433	+2.478	<.001	.001	3	2
UCEC	TMED8 →	+0.356	+1.687	.007	.006	3	2
UCEC	FUZ →	-0.746	-1.766	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,319 associations by consensus.

OR4F5 by SPHK2 expression — KIRC

Explore this box plot interactively →