SPHK2

Across TCGA patient cohorts, SPHK2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPHK2-associated genes across cancer lineages are Notch1, 14-3-3_beta, and Caspase-8. Each is linked with SPHK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SPHK2-low versus SPHK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.137	+1.765	.009	.014	3	3
UCEC	14-3-3_beta →	-0.082	-3.558	.029	.002	3	2
UCEC	Caspase-8 →	-0.278	-2.973	.003	<.001	3	2
UCEC	ERK2 →	+0.168	+2.169	.020	.003	3	1
UCEC	JNK2 →	+0.274	+2.710	<.001	.003	3	1
UCEC	Ku80 →	+0.281	+2.013	.001	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Notch1 by SPHK2 expression — UCEC

Explore this box plot interactively →