SPHK2

Across TCGA cell cohorts, SPHK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,797 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SPHK2-associated GO terms across cancer lineages are Positive regulation of sphingolipid biosynthetic process, Positive regulation of ceramide biosynthetic process, and Transcription initiation-coupled chromatin remodeling. Each is linked with SPHK2 in more than 16 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of sphingolipid biosynthetic process grouped by SPHK2-low versus SPHK2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Positive regulation of sphingolipid biosynthetic process →	+0.202	+1.040	.001	<.001	3	17
SKIN	Positive regulation of ceramide biosynthetic process →	+0.202	+1.040	.001	<.001	3	17
LIVER	Transcription initiation-coupled chromatin remodeling →	+0.087	+1.046	.002	.002	3	17
LUNG_NSCLC_LUSC	Copper ion export →	-0.162	-0.994	<.001	<.001	2	15
OESOPHAGUS	Positive regulation of T-helper 17 cell lineage commitment →	+0.219	+1.061	.008	<.001	3	13
LIVER	Positive regulation of gene expression, epigenetic →	+0.095	+1.317	.002	.002	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,797 associations by consensus.

Positive regulation of sphingolipid biosynthetic process by SPHK2 expression — SKIN

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