SPHK2

Across TCGA cell cohorts, SPHK2 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SPHK2-associated genes across cancer lineages are IQCF2, ARFRP1, and CENPI. Each is linked with SPHK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPHK2-to-partner and partner-to-SPHK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF2 grouped by SPHK2-low versus SPHK2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK2→partner) and Y-score (partner→SPHK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IQCF2 →	+0.052	+5.196	<.001	.005	3	1
BLOOD_Leukemia	ARFRP1 →	+0.509	+2.489	.002	.007	3	1
BLOOD_Leukemia	CENPI →	+0.641	+2.489	.006	.007	3	1
BLOOD_Leukemia	ERICH1 →	+0.459	+2.489	.007	.007	3	1
BLOOD_Leukemia	GHRHR →	+0.168	+2.442	<.001	.003	3	1
BLOOD_Leukemia	ANAPC15 →	+0.585	+3.115	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

IQCF2 by SPHK2 expression — OVARY

Explore this box plot interactively →