SPHK1

Across TCGA patient cohorts, SPHK1 mutation is significantly associated with the RNA expression of many other genes, with 474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPHK1-associated genes across cancer lineages are CYP4F36P, RNU4-58P, and MIR920. Each is linked with SPHK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPHK1-to-partner and partner-to-SPHK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP4F36P grouped by SPHK1-low versus SPHK1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPHK1→partner) and Y-score (partner→SPHK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CYP4F36P →	+0.403	+3.342	.001	.007	3	2
UCEC	RNU4-58P →	+0.193	+2.433	.002	.009	3	2
CESC	MIR920 →	+0.438	+5.539	<.001	.004	3	1
CESC	RNA5SP294 →	+0.450	+5.103	<.001	.008	3	1
CESC	LINC00708 →	+0.042	+5.418	.001	.005	3	1
SKCM	RN7SL107P →	+0.213	+5.771	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 474 associations by consensus.

CYP4F36P by SPHK1 expression — STAD

Explore this box plot interactively →