Across TCGA pan-cancer cohorts, SPG7 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SPG7 data layer compared with 23 for mass-spec protein and 6 for mass-spec protein.
The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SPG7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SPG7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CESC show a favorable association.
LUAD, UCEC, and MESO are the cancer types where SPG7 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.