Across TCGA patient cohorts, SPG7 protein abundance is significantly associated with the RNA expression of many other genes, with 11,100 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPG7-associated genes across cancer lineages are GYPC, AFG3L2, and FILIP1L. Each is linked with SPG7 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPG7-to-partner and partner-to-SPG7 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG7→partner) and Y-score (partner→SPG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GYPC →	-0.788	-0.570	.002	<.001	3	5
LSCC	AFG3L2 →	+0.473	+0.294	<.001	<.001	3	5
UCEC	FILIP1L →	-0.679	-0.379	<.001	<.001	3	5
BRCA	RASSF2 →	-0.765	-0.416	<.001	<.001	3	4
UCEC	RASL12 →	-0.839	-0.334	<.001	<.001	3	4
GBM	TFEC →	-0.704	-0.221	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,100 associations by consensus.

Exploration

SPG7 survival (RNA) · tumor vs normal (RNA) · all SPG7 data types