Across TCGA patient cohorts, SPG7 mutation is significantly associated with the RNA expression of many other genes, with 3,019 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPG7-associated genes across cancer lineages are ZFYVE19, YARS1, and SSRP1. Each is linked with SPG7 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPG7-to-partner and partner-to-SPG7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG7→partner) and Y-score (partner→SPG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ZFYVE19 →	+0.486	+3.951	<.001	<.001	3	4
UCEC	YARS1 →	+0.539	+1.911	<.001	<.001	3	4
UCEC	SSRP1 →	+0.480	+3.054	<.001	<.001	3	3
UCEC	SKA1 →	+0.676	+2.523	<.001	<.001	3	3
UCEC	CCNB2 →	+0.622	+2.938	<.001	<.001	3	3
UCEC	RER1 →	+0.264	+4.201	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,019 associations by consensus.

Exploration

SPG7 survival (RNA) · tumor vs normal (RNA) · all SPG7 data types