Across TCGA patient cohorts, SPG7 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPG7-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and Fibronectin. Each is linked with SPG7 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPG7-to-partner and partner-to-SPG7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG7→partner) and Y-score (partner→SPG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.165	+2.169	<.001	.003	3	4
UCEC	Caspase-7-cleavedD198 →	+0.732	+2.189	<.001	.001	3	3
UCEC	Fibronectin →	-0.274	-1.668	.010	.021	3	2
UCEC	GAPDH →	+0.439	+2.000	.011	.009	3	2
UCEC	ACVRL1 →	-0.135	-1.893	.002	.014	3	2
UCEC	JNK2 →	+0.285	+2.000	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Exploration

SPG7 survival (RNA) · tumor vs normal (RNA) · all SPG7 data types