SPG21

Across TCGA patient cohorts, SPG21 protein abundance is significantly associated with the RNA expression of many other genes, with 9,656 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPG21-associated genes across cancer lineages are SLC15A3, TYROBP, and PELATON. Each is linked with SPG21 in more than 4 cancer types. Because this analysis shows association rather than direction, both SPG21-to-partner and partner-to-SPG21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPG21 versus SLC15A3 in GBM, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG21→partner) and Y-score (partner→SPG21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC15A3 →	+0.630	+0.182	.001	.008	3	5
COAD	TYROBP →	+0.736	+0.207	<.001	<.001	3	5
COAD	PELATON →	+0.629	+0.245	<.001	<.001	3	5
COAD	AQP9 →	+1.239	+0.290	<.001	<.001	3	4
GBM	CTSL →	+0.992	+0.240	<.001	.001	3	4
COAD	LCP1 →	+0.774	+0.198	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,656 associations by consensus.

SPG21 vs SLC15A3 — GBM

Explore this scatter interactively →