SPG11

Across TCGA patient cohorts, SPG11 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,964 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SPG11-associated proteins across cancer lineages are RTF1, SRP9, and UBR1. Each is linked with SPG11 in more than 5 cancer types. Because this analysis shows association rather than direction, both SPG11-to-partner and partner-to-SPG11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPG11 versus RTF1 in LSCC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG11→partner) and Y-score (partner→SPG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RTF1 →	+0.351	+0.418	<.001	<.001	3	5
LSCC	SRP9 →	+0.279	+0.271	.001	.007	2	6
BRCA	UBR1 →	+0.270	+0.690	<.001	<.001	3	5
GBM	P4HB →	-0.373	-0.165	<.001	.008	3	5
LSCC	IGF1R →	+0.545	+0.293	<.001	.008	2	5
BRCA	SHMT2 →	-0.534	-0.777	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,964 associations by consensus.

SPG11 vs RTF1 — LSCC

Explore this scatter interactively →