SPG11

Across TCGA pan-cancer cohorts, SPG11 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SPG11’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SPG11 RNA is repressed in tumor relative to normal tissue. In most cancer types SPG11 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and CHOL are the cancer types where SPG11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPG11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.461	<.001	8	view →
LIHC	Female	All	+0.710	<.001	7	view →
CHOL	All	All	+1.378	<.001	5	view →
STAD	Male	II,III,IV	+0.674	.023	2	view →
KICH	All	All	−0.402	.010	2	view →
COAD	Female	All	−0.318	.027	2	view →
PRAD	All	All	+0.266	.032	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SPG11–THCA

Open the THCA breakdown →