SPG11

Across TCGA patient cohorts, SPG11 protein abundance is significantly associated with the protein abundance of many other proteins, with 20,742 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SPG11-associated proteins across cancer lineages are ZFYVE26, AP5B1, and ZFYVE26_S144. Each is linked with SPG11 in more than 8 cancer types. Because this analysis shows association rather than direction, both SPG11-to-partner and partner-to-SPG11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SPG11 versus ZFYVE26 in LSCC, with a Pearson correlation of 0.93.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG11→partner) and Y-score (partner→SPG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ZFYVE26 →	+0.350	+0.317	<.001	<.001	3	9
GBM	AP5B1 →	+0.300	+0.213	<.001	<.001	3	9
LSCC	ZFYVE26_S144 →	+0.815	+0.222	<.001	<.001	3	8
LSCC	AP5Z1 →	+0.276	+0.297	<.001	<.001	3	8
UCEC	VTI1B →	+0.401	+0.264	<.001	<.001	2	8
BRCA	ZFYVE26_S297 →	+0.699	+0.258	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,742 associations by consensus.

SPG11 vs ZFYVE26 — LSCC

Explore this scatter interactively →