SPG11

Across TCGA patient cohorts, SPG11 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPG11-associated genes across cancer lineages are FoxM1, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with SPG11 in more than 3 cancer types. Because this analysis shows association rather than direction, both SPG11-to-partner and partner-to-SPG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SPG11-low versus SPG11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG11→partner) and Y-score (partner→SPG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.175	+1.447	.016	.002	3	4
UCEC	Caspase-7-cleavedD198 →	+0.842	+2.201	<.001	<.001	3	4
COAD	Cyclin-E2 →	+0.218	+3.025	.030	.018	3	4
STAD	GAPDH →	+0.380	+3.000	.024	.034	3	3
COAD	C-Raf →	+0.178	+3.034	.005	.017	3	3
SKCM	Smad4 →	+0.077	+1.908	.045	.026	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

FoxM1 by SPG11 expression — UCEC

Explore this box plot interactively →