SPG11

Across TCGA cell cohorts, SPG11 mutation is significantly associated with the RNA expression of many other genes, with 419 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SPG11-associated genes across cancer lineages are TGIF2LY, AVP, and OR2A5. Each is linked with SPG11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPG11-to-partner and partner-to-SPG11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGIF2LY grouped by SPG11-low versus SPG11-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPG11→partner) and Y-score (partner→SPG11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TGIF2LY →	+0.056	+4.643	<.001	.008	3	2
BLOOD_Lymphoma	AVP →	+0.019	+3.472	<.001	.002	3	2
BLOOD_Leukemia	OR2A5 →	+0.010	+2.922	.002	.009	3	2
BREAST	KCNA6 →	+0.004	+3.378	<.001	.006	3	2
LARGE_INTESTINE	ESS2 →	+0.480	+3.169	.006	.009	3	2
LARGE_INTESTINE	DBR1 →	+0.503	+3.169	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 419 associations by consensus.

TGIF2LY by SPG11 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →