SPESP1

Across TCGA patient cohorts, SPESP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,818 significant associations in total. STAD shows the largest number of these associations.

The most reproducible SPESP1-associated GO terms across cancer lineages are Endothelial cell migration, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway, and Regulation of actomyosin structure organization. Each is linked with SPESP1 in more than 14 cancer types. Because this analysis shows association rather than direction, both SPESP1-to-partner and partner-to-SPESP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cell migration grouped by SPESP1-low versus SPESP1-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPESP1→partner) and Y-score (partner→SPESP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Endothelial cell migration →	+0.054	+0.470	<.001	<.001	3	15
STAD	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.039	+0.492	<.001	<.001	3	15
STAD	Regulation of actomyosin structure organization →	+0.063	+0.609	<.001	<.001	3	14
ESCA	Positive regulation of cell-substrate junction organization →	+0.066	+0.800	<.001	.002	2	15
DLBC	Obsolete positive regulation of ER-associated ubiquitin-dependent protein catabolic process →	+0.101	+0.540	.001	.002	3	14
STAD	Smooth muscle cell migration →	+0.064	+0.617	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,818 associations by consensus.

Endothelial cell migration by SPESP1 expression — STAD

Explore this box plot interactively →