SPESP1

Across TCGA pan-cancer cohorts, SPESP1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SPESP1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where SPESP1 RNA is repressed in tumor relative to normal tissue. In most cancer types SPESP1 is over-expressed in tumor, although a few such as UCEC and KICH show the opposite, repressed pattern.

UCEC, KICH, and KIRC are the cancer types where SPESP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SPESP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	II,III,IV	−1.834	<.001	8	view →
KICH	All	All	−1.681	<.001	7	view →
KIRC	Male	II,III,IV	−0.768	<.001	6	view →
STAD	All	All	−0.698	<.001	6	view →
COAD	Female	All	−0.493	<.001	5	view →
KIRP	Female	All	−1.660	<.001	4	view →
READ	All	All	−0.860	.001	3	view →
THCA	Female	All	−0.510	.024	1	view →
CHOL	Female	All	−0.450	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SPESP1–UCEC

Open the UCEC breakdown →